HCID 69491897, compound → HCID 69490626, compound

HRID 1768152Notes

Reaction equation

HRID 1768152 reaction equation
[C:1]([O:5][C:6](=[O:28])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19]CC3C=CC=CC=3)=[CH:15][CH:14]=2)[C:9]1=[O:27])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:28])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=2)[C:9]1=[O:27])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69491897HCID 69491897, compound

Product 1

HCID 69490626HCID 69490626, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In an analogous manner to that described in Example 2b), the hydrogenolysis of the (S)-[1-(4-benzyloxy-phenyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester [Example 8 b)] using palladium on carbon as the catalyst yields the title compound as a white solid in quantitative yield; MS: m/e=291 (M−H)+.

Sources & evidence

ORD record
ord-9f0bf6a7caa84159b2440e8160bcdcc3
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Reaction notes

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