Cyclohexylamine → N-Cyclohexyl-2-(quinoline-8-sulfonylamino)-benzamide

HRID 1768321Notes

Reaction equation

HRID 1768321 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[S:18]([NH:21][C:22]2[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=2[C:24](Cl)=[O:25])(=[O:20])=[O:19])[CH:11]=[CH:10][CH:9]=1>>[CH:1]1([NH:7][C:24](=[O:25])[C:23]2[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=2[NH:21][S:18]([C:16]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:17]=2[N:8]=[CH:9][CH:10]=[CH:11]3)(=[O:20])=[O:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 120206732-(Quinoline-8-sulfonylamino)-benzoyl chloride

Product 1

HCID 7573778N-Cyclohexyl-2-(quinoline-8-sulfonylamino)-benzamideYield 57.4%

Procedure

50 mg of cyclohexylamine were reacted with 87 mg of 2-(quinoline-8-sulfonylamino)-benzoyl chloride in analogy to example 1 which resulted in 59 mg of an amorphous white solid. MS (ES): 410 (M+H)+

Sources & evidence

ORD record
ord-6b1dad617afb4a72ba27f5ada301573b
Source dataset
uspto-grants-2007_06
Patent number
US07235664B2

Reaction notes

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