Formaldehyde → HCID 22065962, compound

HRID 1768352Notes

Reaction equation

HRID 1768352 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[N:10]1([C:16]2[N:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:22]([O-])(=O)C.[Na+].C=O>>[N:21]1[CH:20]=[CH:19][CH:18]=[N:17][C:16]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:22][C:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[NH:1][CH:2]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 887471-(2-Pyrimidinyl)piperazineHCID 517045Sodium Acetate

Product 1

HCID 22065962HCID 22065962, compound

Procedure

1H-pyrrolo[2,3-b]pyridine (47 mg, 0.40 mmol), 2-(1-piperazinyl)pyrimidine (65 mg, 0.48 mmol), sodium acetate (72 mg, 0.53 mmol), and formaldehyde (0.48 mmol) were processed as described in Example 18 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 2.42 (m, 4H) 3.68 (m, 4H) 4.05 (s, 2H) 5.59 (s, 1H) 6.60 (m, 1H) 7.08 (m, 2H) 7.37 (m, 2H 8.07 (m, 2H). (ESI) m/z 295 (M+H)+.

Sources & evidence

ORD record
ord-e8ab563a9c8647189665973f49e7fd00
Source dataset
uspto-grants-2007_06
Patent number
US07235661B2

Reaction notes

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