Hydrate;hydrochloride → HCID 69507248, compound

HRID 1768414Notes

Reaction equation

HRID 1768414 reaction equation
[C:1]([CH:3]1[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=2)=[C:11]2[C:6](=[C:7]3[CH:22]=[CH:21][N:20]=[C:8]3[CH:9]=[CH:10]2)[O:5][C:4]1=N)#[N:2].Cl.[OH2:25]>>[C:1]([CH:3]1[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=2)=[C:11]2[C:6](=[C:7]3[CH:22]=[CH:21][N:20]=[C:8]3[CH:9]=[CH:10]2)[O:5][C:4]1=[O:25])#[N:2]

Participants

3

Reactant 2

HCID 21885828Hydrate;hydrochlorideHCID 86588471HCID 86588471, compound

Product 1

HCID 69507248HCID 69507248, compound

Procedure

The process further comprises contacting the 2-iminobenzopyran with an aqueous acid to produce an optionally substituted coumarin (2-oxo-2H-chromene). For example, the hydrolysis of 3-cyano-2-imino-4-(5-methyl-pyridin-3-yl)-2H-pyrrolo[2,3-h]chromene using HCl/H2O produced 3-cyano-4-(5-methyl-pyridin-3-yl)-2-oxo-2H-pyrrolo[2,3-h]chromene (compound of Formula III).

Sources & evidence

ORD record
ord-27f6078d06604b1588328691637df65a
Source dataset
uspto-grants-2007_06
Patent number
US07235674B2

Reaction notes

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