3-Aminophenol → HCID 10201027, compound

HRID 1768425Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C([O:11][C:12](=O)[C:13]([C:26]#[N:27])=[CH:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([Br:25])[CH:16]=1)C>>[NH2:1][C:2]1[CH:3]=[C:4]2[C:5]([C:14]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([Br:25])[CH:16]=3)=[C:13]([C:26]#[N:27])[C:12](=[O:11])[O:8]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 115683-Aminophenol

HCID 69507278HCID 69507278, compound

Product 1

HCID 10201027HCID 10201027, compoundYield 7%

Procedure

The title compound was prepared from 3-aminophenol and 3-(3-bromo-4,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester by a procedure similar to that described for Example 16 in 7% yield. 1H NMR (CDCl3): 7.20-7.16 (m, 2H), 6.96 (d, J=2.1 Hz, 1H), 6.59-6.55 (m, 2H), 4.63 (brs, 2H), 3.96 (s, 3H), 3.92 (s, 3H).

Sources & evidence

ORD record: ord-fc0fe04f068a45aebe8304b01fd786df
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235674B2

Reaction notes

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