3-(Dimethylamino)phenol → HCID 10274221, compound

HRID 1768426Notes

Reaction equation

HRID 1768426 reaction equation
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C([O:13][C:14](=O)[C:15]([C:28]#[N:29])=[CH:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([Br:27])[CH:18]=1)C>>[C:28]([C:15]1[C:14](=[O:13])[O:9][C:5]2[C:6]([C:16]=1[C:17]1[CH:22]=[C:21]([O:23][CH3:24])[C:20]([O:25][CH3:26])=[C:19]([Br:27])[CH:18]=1)=[CH:7][CH:8]=[C:3]([N:2]([CH3:10])[CH3:1])[CH:4]=2)#[N:29]

Participants

3

Reactant 2

HCID 74213-(Dimethylamino)phenolHCID 69507278HCID 69507278, compound

Product 1

HCID 10274221HCID 10274221, compoundYield 0.5%

Procedure

The title compound was prepared from 3-dimethylaminophenol and 3-(3-bromo-4,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester by a procedure similar to that described for Example 16 in 0.5% yield. 1H NMR (CDCl3): 7.21-7.18 (m, 2H), 6.98 (d, J=1.8 Hz, 1H), 6.62 (dd, J=2.4, 9 Hz, 1H), 6.53 (d, J=2.7 Hz, 1H), 3.96 (s, 3H), 3.92 (s, 3H), 3.15 (s, 6H).

Sources & evidence

ORD record
ord-3f53d80ad9d94e33ac46044f09544a6c
Source dataset
uspto-grants-2007_06
Patent number
US07235674B2

Reaction notes

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