3-Aminophenol → HCID 22229232, compound

HRID 1768427Notes

Reaction equation

HRID 1768427 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C([O:11][C:12](=O)[C:13]([C:25]#[N:26])=[CH:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[CH:16]=1)C>>[NH2:1][C:2]1[CH:3]=[C:4]2[C:5]([C:14]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[CH:16]=3)=[C:13]([C:25]#[N:26])[C:12](=[O:11])[O:8]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 2732672HCID 2732672, compound

Product 1

HCID 22229232HCID 22229232, compoundYield 0.5%

Procedure

The title compound was prepared from 3-aminophenol and 3-(3,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester by a procedure similar to that described for Example 16 in 0.5% yield. 1H NMR (CDCl3): 7.42 (d, J=8.4 Hz, 1H), 6.72 (d, J=2.4 Hz, 2H), 6.61-6.60 (m, 1H), 6.20 (d, J=2.1 Hz, 1H), 6.10 (dd, J=2.1, 8.7 Hz, 1H), 4.30 (brs, 2H), 3.83 (s, 6H).

Sources & evidence

ORD record
ord-13c2e1bf28524ddda4779f5b7dca1db7
Source dataset
uspto-grants-2007_06
Patent number
US07235674B2

Reaction notes

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