1-Butanol → HCID 13315698, compound

Participants

Reaction Steps

540 g (5.0 mol) o-cresol, 500 g n-butanol and 560 g (5.0 mol) 50% (m/m) potassium hydroxide solution are initially introduced and heated under reflux, the water being removed azeotropically. 463 g (5.0 mol) n-butyl chloride are then metered in under reflux in the course of 2 h, further water being cycled out. After metering, the reaction mixture is stirred for a further 2 h, cooled to 80° C., hydrolysed with 800 g water and adjusted to pH 4 with 50% (m/m) sulphuric acid. The phases are separated at 70° C. After distillation, 794 g product with a purity of 94% is obtained.

Provenance & Evidence