Methyl iodide → HCID 11772916, compound

Participants

Reaction Steps

To a solution of xiii (10 mg, 0.029 mmol) in CH3CN (1 mL) was added cesium carbonate (14 mg, 0.043 mmol) and methyl iodide (3.5 mL, 0.57 mmol) and the mixture was stirred at room temperature for 12 hours. The mixture was diluted with water (10 mL) and extracted with EtOAc (3×10 mL). The organic extracts were combined, washed with brine and dried over MgSO4. The solvent was removed under reduced pressure and the residue was purified by preparative thin layer chromatography to provide compounds xv (6.2 mg, 60%).

Provenance & Evidence