Sodium Hydroxide → HCID 10046528, compound

Participants

Reaction Steps

To 350 mg (0.85 mmol) of ester 19-1 in a 1:1:1 mixture of THF/MeOH/H2O was added 170 mg (4.25 mmol) of NaOH. After stirring overnight at room temperature, the reaction was quenched with 1M HCl and then extracted three times with EtOAc. The combined organic phase was washed with brine, dried over MgSO4, and concentrated to provide 24-1 as a white solid. Data for 24-1: 1HNMR (500 MHz, d6-DMSO) δ 12.0 (s, 1H), 7.5-7.1 (m, 8H), 6.2 (s, 1H), 4.95 (m, 1H), 4.7 (m, 1H), 3.0 (m, 1H), 2.75 (s, 6H), 2.45 (m, 1H), 2.2 (m, 2H) ppm. HRMS (ES) calc'd M+H for C22H22F2N2O3: 401.1671. Found: 401.1695.

Provenance & Evidence