Benzylamine → HCID 22903014, compound

HRID 1768509Notes

Reaction equation

HRID 1768509 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH:14]([CH2:21][CH3:22])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[CH:7][CH:6]=1)(=O)C.C(N)C1C=CC=CC=1>C(O)C.C(Cl)(Cl)Cl>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([O:13][CH:14]([CH2:21][CH3:22])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:12])=[CH:9][CH:10]=1

Participants

5

Reactant 2

HCID 7504BenzylamineHCID 18947997HCID 18947997, compound

Product 1

HCID 22903014HCID 22903014, compoundYield 67.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6212ChloroformSolvent

Procedure

The crude final product (2) (1.9 g) was dissolved in 50 ml of ethanol, and 4 g of benzylamine was added dropwise. The mixture was stirred at room temperature for 4 hours, then diluted with 500 ml of chloroform, washed with dilute hydrochloric acid and water in this sequence, and dried over magnesium sulfate. After the solvent was evaporated, the solid was purified by silica gel column chromatography to obtain 1.1 g of a final product (3).

Workup

  1. washwashed with dilute hydrochloric acid and water in this sequence
  2. dry with materialdried over magnesium sulfate
  3. customAfter the solvent was evaporated
  4. customthe solid was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-ac7f8fd14cd8444bb8e370d7a99d89af
Source dataset
uspto-grants-1995_01
Patent number
US05378396

Reaction notes

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