2-Hydroxyquinoline → HCID 135795658, compound

HRID 1768529Notes

Reaction equation

[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([OH:18])=[CH:10][C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C2C(=CC=CC=2)C=C[C:21]1=[O:30]>>[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([OH:18])=[C:10]([CH:21]=[O:30])[C:9]1=[O:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 60382-Hydroxyquinoline

HCID 546808631-Benzyl-4-hydroxyquinolin-2(1H)-one

Product 1

HCID 135795658HCID 135795658, compound

Procedure

Following the Procedure set forth in Preparation B, 1-benzyl-4-hydroxy-2(1H)-quinolinone was converted to 1-benzyl-3-formyl-4-hydroxy-(2(1H)-quinolinone. That the expected product was obtained was confirmed by the spectral data: MS (FAB): m/e 370 (M·+ +1); NMR (DMSO): δ5.50 (s, 2H, CH2 --Ar), 10.18 (s, 1H, CHO) ppm.

Sources & evidence

ORD record: ord-299e211840e74b579386ce6b64e48455
Source dataset: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05378694

Reaction notes

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