1-Bromohexane → 2-Hydroxyquinoline

Participants

Reaction Steps

Following the procedure set forth in Steps (2) to (4) of Preparation A, isatoic anhydride was reacted with hexyl bromide to give 1-hexyl-4-hydroxy-(2(1H)-quinolinone. That the expected product was obtained was confirmed by the spectral data: MS: role 245 (M·+); NMR (DMSO): δ0.9 (t, 3H, CH3 --CH2 --), 4.06 (t, 2H, N--OH2), 6.18 (s, 1H, =CH), 11.87 (br, 1H, OH) ppm.

Provenance & Evidence