O-Ethyl hydrazinecarbothioate → Hydrochloric Acid

Participants

Reaction Steps

A solution of 1.7 g of 1-(N-ethyl-p-methoxybenzimidoyl)-6-(2-chloro-2-methylpropionyl)-1,2,3,4-tetrahydroquinoline in 40 ml of acetonitrile is treated with 1 equivalent of O-ethyl hydrazinothioformate and the mixture is boiled for 2 hours. After customary working up, 5-[1-(N-ethyl-p-methoxybenzimidoyl)-1,2,3,4-tetrahydroquinolin-6-yl]-6,6-dimethyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one, m.p. 244° (hydrochloride), is obtained.

Provenance & Evidence