Toluene → HCID 18948846, compound

Participants

Reaction Steps

The product of Step A (0.68 g, 4.0 mmole) and 4,5-dichloro-6-ethylpyrimidine (0.71 g, 4.0 mmole) were dissolved in triethylamine (1.1 mL, 8.0 mmole) and toluene (7 mL) and heated to reflux for 4 hours. After cooling, the reaction mixture was treated with 20 mL of water and 30 mL of ether, partitioned, and the aqueous phase extracted with ether. The combined organic phases were dried (MgSO4), concentrated and chromatographed on silica gel with 10% ethyl acetate/hexane. The title compound was obtained as a white solid (0.77 g, 62% yield) , mp 81°-83° C.

Provenance & Evidence