5-Isocyanato-1,3-dioxaindane → HCID 178456221, compound

HRID 1768570Notes

Reaction equation

HRID 1768570 reaction equation
[OH:1][CH:2]([CH3:20])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[C:18]3[C:13](=[CH:14][C:15]([F:19])=[CH:16][CH:17]=3)[NH:12][N:11]=2)[CH2:6][CH2:5]1.[CH2:21]1[O:29][C:28]2[CH:27]=[CH:26][C:25]([N:30]=[C:31]=[O:32])=[CH:24][C:23]=2[O:22]1>>[CH2:21]1[O:29][C:28]2[CH:27]=[CH:26][C:25]([NH:30][C:31]([O:1][CH:2]([CH3:20])[CH2:3][N:4]3[CH2:5][CH2:6][CH:7]([C:10]4[C:18]5[C:13](=[CH:14][C:15]([F:19])=[CH:16][CH:17]=5)[NH:12][N:11]=4)[CH2:8][CH2:9]3)=[O:32])=[CH:24][C:23]=2[O:22]1

Participants

3

Reactant 2

HCID 52232135-Isocyanato-1,3-dioxaindaneHCID 178468210HCID 178468210, compound

Product 1

HCID 178456221HCID 178456221, compoundYield 9%

Procedure

Starting from 3-[1-(2-hydroxyprop-1-yl)-4-piperidinyl]-6-fluoro-1H-indazole (300 mg, 1.1 mmol) and 3,4-methylenedioxyphenylisocyanate (380 mg, 2.2 mmol) using the procedure described in example 12A was prepared 40 mg (9%) of the title compound as an amorphous solid.

Sources & evidence

ORD record
ord-809bba06ed114612ac089d5acf7f708a
Source dataset
uspto-grants-1995_01
Patent number
US05378714

Reaction notes

Loading…