Morpholine → HCID 18948430, compound

Participants

Reaction Steps

A mixture of 2 g (6.4 mmole) of t-butyl 4,5-epoxy-2-(1-naphthylmethyl)pentanoate (prepared as described in Preparation 11), 0.84 ml of morpholine and 50 ml of methanol was stirred at room temperature for 6 hours and then allowed to stand overnight. The reaction mixture was then concentrated by evaporation under reduced pressure. The residue was purified by column chromatography through silica gel (eluent: a 10 : 90 by volume mixture of methanol and methylene chloride), to afford 1.96 g (76.6%) of the title compound as a pale yellow oil.

Provenance & Evidence