反应详情

7.5 g (30 mmole) of 2-(1-naphthylmethylene)glutaric anhydride (prepared as described above) were dissolved in 70 ml of methylene chloride, and 2.85 ml (33 mmole) of morpholine were added to the resulting solution. The mixture was stirred at room temperature for 4 hours. At the end of this time, the reaction mixture was washed with a 5% v/v aqueous solution of citric acid and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate and freed from the solvent by evaporation under reduced pressure, to give 10.0 g (30 mmole) of 5-morpholino-2-(1-naphthylmethylene)-5-oxopentanoic acid.

1. washAt the end of this time, the reaction mixture was washed with a 5% v/v aqueous solution of citric acid and with a saturated aqueous solution of sodium chloride, in that order
2. dry with materialafter which it was dried over anhydrous sodium sulfate
3. customfreed from the solvent by evaporation under reduced pressure