反应详情

2.85 ml (33 mmole) of morpholine were added to a solution of 7.5 g (30 mmole) of the 2-(1-naphthylmethylene)glutaric anhydride prepared as described above dissolved in 70 ml of methylene chloride, and the mixture was stirred at room temperature for 4 hours. It was then washed with a 5% w/v aqueous solution of citric acid and with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, to give 10.0 g (30 mmole) of 4-morpholinocarbonyl-2-(1-naphthylmethylene)butyric acid.

1. customprepared
2. washIt was then washed with a 5% w/v aqueous solution of citric acid and with a saturated aqueous solution of sodium chloride
3. dry with materialdried over anhydrous sodium sulfate
4. customThe solvent was then removed by distillation under reduced pressure