Pyridine → HCID 54542434, compound

HRID 1768646Notes

Reaction equation

HRID 1768646 reaction equation
O[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3[CH:19]=[CH:20][CH:21]=[CH:22][C:10]=3[CH2:9][O:8][C:7]=2[CH:23]=1.S(Cl)([Cl:26])=O.N1C=CC=CC=1>ClCCl>[Cl:26][CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:12](=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:11]3[CH:19]=[CH:20][CH:21]=[CH:22][C:10]=3[CH2:9][O:8][C:7]=2[CH:23]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 54512316HCID 54512316, compound

Product 1

HCID 54542434HCID 54542434, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 1-b (6.58 g) was dissolved in 200 ml of dichloromethane, and 6.2 ml of thionyl chloride and 6.9 ml of pyridine were added to the solution. The mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure. The obtained product was unstable and immediately subjected to the subsequent reaction without purification.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customimmediately subjected to the subsequent reaction without purification

Sources & evidence

ORD record
ord-cbe3a5177ca04f56aa6bb582c8ea15c9
Source dataset
uspto-grants-1995_01
Patent number
US05378701

Reaction notes

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