Ethanethiol → HCID 14860709, compound

HRID 1768687Notes

Reaction equation

HRID 1768687 reaction equation
[C:1]([NH:4][CH:5]([S:16][CH3:17])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])(=[O:3])[CH3:2].[C:18](NC(OCC)C(NCC1C=CC=CC=1)=O)(=O)C.CCS>>[C:1]([NH:4][CH:5]([S:16][CH2:17][CH3:18])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 14212862HCID 14212862, compoundHCID 14860708HCID 14860708, compound

Product 1

HCID 14860709HCID 14860709, compoundYield 38%

Procedure

Using the procedure described for the synthesis of 2-acetamido-N-benzyl-2-(methylmercapto)acetamide, 2-acetamido-N-benzyl-2-ethoxyacetamide (2.00 g, 8.0 mmol) and EtSH (0.65 g, 10.4 mmol) were converted to 0.80 g (38%) of the desired product. The compound was further purified by recrystallization from chloroform/hexane to give a beige solid. Rf 0.60 (4% MeOH/CHCl3). mp 146°-148° C.

Sources & evidence

ORD record
ord-5266bf7c5abe4222bff3e9c18eabc5c7
Source dataset
uspto-grants-1995_01
Patent number
US05378729

Reaction notes

Loading…