HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1768741Generated: November 3, 2026
Diisopropylcarbodiimide → HCID 18949408, compound
https://huagongshe.com/reaction/1768741
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | HCID 303574 | HCID 303574 | — |
| Reactant | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18949408 | HCID 18949408 | 75.8% |
Reaction Steps
A mixture of 11.4 g of 1-trifluoroacetylaminocyclopentanecarboxylic acid and 10.4 g of 5,6-diamino-1,3-dipropyluracil in 120 ml of methanol was treated with 8.7 ml of diisopropylcarbodiimide (DIPC). After 2 hours stirring at room temperature and 1 h at 4° C., the formed precipitate is filtered under vacuum, washed and dried, thereby obtaining 15.1 g of 6-amino-1,3-dipropyl-5-(1-trifluoroacetylamino cyclopentanecarboxamido)uracil m.p. 203°-4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05378844 |
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| Source dataset | uspto-grants-1995_01 |
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| ORD ID | ord-c802577f4f3a497cb8fb116e858b5a84 |
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| Source note | uspto-grants-1995_01 |
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