HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide → 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[[(1,1-dimethylethoxy)carbonyl](2-furanylmethyl)amino]-1-oxopropyl]hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide | HCID 13560461 | — |
| Reactant | 3-{[(Tert-butoxy)carbonyl][(furan-2-yl)methyl]amino}propanoic acid | HCID 23369391 | — |
| Reactant | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[[(1,1-dimethylethoxy)carbonyl](2-thienylmethyl)-amino]-1-oxopropyl]hydrazide | HCID 86748363 | — |
| Product | 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[[(1,1-dimethylethoxy)carbonyl](2-furanylmethyl)amino]-1-oxopropyl]hydrazide | HCID 86748365 | — |
Reaction Steps
8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[[(1,1-dimethylethoxy)carbonyl](2-furanylmethyl)amino]-1-oxopropyl]hydrazide (24) was prepared in the same manner as 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[[(1,1-dimethylethoxy)carbonyl](2-thienylmethyl)amino]-1-oxopropyl]hydrazide (17), as described above in Example 17, on a 0.63 mmol scale from 3-[[(1,1-dimethylethoxy)carbonyl](2-furanylmethyl)-amino]propanoic acid (23), prepared as described above in Example 23, and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)carboxylic acid, hydrazide (1), prepared as described above in Example 1, to yield 0.24 g (71%) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05378840 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-8bb65f814fcb4656bf12dcd3eb4f26b3 |
| Source note | uspto-grants-1995_01 |