2(R)-benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionic acid → (2S, 4S, 5S)-5-{N-[2(R)-Benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Participants

Reaction Steps

The procedure described in Example 2(b) was repeated, but using 280 mg (0.48 mmole) of (2S, 4S, 5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl )-L-alanyl]amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide [prepared as described in Example 2(a)] and 150 mg (0.48 mmole) of 2(R)-benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionic acid, to afford 187 mg of the title compound as a white powder, melting at 155°-156° C.

Provenance & Evidence