2(R)-benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionic acid → (2R, 4S, 5S)-5-{N-[2(R)-Benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionyl]-3-(4-thiazolyl)-L-alanyl}amino-6-cyclohexyl-4-hydroxy-N-isobutyl-2-methylhexanamide

Participants

Reaction Steps

The procedure described in Example 6(b) was repeated, but using 300 mg (0.543 mmole) of (2R, 4S, 5S)-5-[N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]amino-6-cyclohexyl-4-hydroxy-N-isobutyl-2-methylhexanamide [prepared as described in Example 17(a)] and 170 mg (0.543 mmole) of 2(R)-benzyl-3-(N-benzyl-N-methylaminocarbonyl)propionic acid, to afford 216 mg of the title compound as a colorless powder, melting at 118°-120° C.

Provenance & Evidence