HRID1768841

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1cscn1)C(=O)O

HCID2734486

未命名化合物

结构：CCCNC(=O)[C@H](C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C

HCID57031843

未命名化合物

PRODUCTS

生成物

结构：CCCNC(=O)[C@H](C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cscn1)NC(=O)OC(C)(C)C

HCID15045768

未命名化合物

收率 78%

PROCEDURE

实验过程

The procedure described in Example 5(a) was repeated, but using 280 mg (0.728 mmole) of (2R, 4S, 5S)-5-(t-butoxycarbonyl)amino-6-cyclohexyl-4-hydroxy-2-methyl-N-propylhexanamide (prepared as described in Preparation 18) and 204 mg (0.75 mmole) of N-(t-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine, to afford 306 mg of the title compound as colorless crystals, melting at 182°-184° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1596f344af094f9ba9d1b7310a8d3a7c
来源数据集: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05378689
来源说明: uspto-grants-1995_01

反应 SMILES

C(O[C:6]([NH:8][C@@H:9]([CH2:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C@@H:10]([OH:20])[CH2:11][C@@H:12]([CH3:19])[C:13]([NH:15][CH2:16][CH2:17][CH3:18])=[O:14])=[O:7])(C)(C)C.[C:28]([O:32][C:33]([NH:35][C@H:36](C(O)=O)[CH2:37][C:38]1[N:39]=[CH:40][S:41][CH:42]=1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([NH:35][C@H:36]([C:6]([NH:8][C@@H:9]([CH2:21][CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1)[C@@H:10]([OH:20])[CH2:11][C@@H:12]([CH3:19])[C:13]([NH:15][CH2:16][CH2:17][CH3:18])=[O:14])=[O:7])[CH2:37][C:38]1[N:39]=[CH:40][S:41][CH:42]=1)=[O:34])([CH3:31])([CH3:29])[CH3:30]