HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 12361097, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | HCID 582449 | HCID 582449 | — |
| Reactant | HCID 18949367 | HCID 18949367 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12361097 | HCID 12361097 | 84% |
Reaction Steps
Oikawa et al. (J. Org. Chem., vol. 42, pp. 1213-1216, 1977) describes preparation of methyl 5-(3-indolyl)-2-methyloxazole-3-carboxylate in 33% yield by oxidation of methyl 2-acetamido-3-(3-indolyl)propionate with DDQ in tetrahydrofuran. Use of aqueous tetrahydrofuran gave methyl 2-acetamido-3-(3-indolyl)-3-oxopropionate in 84% yield. Preparation of the corresponding thiazole or imidazole is not described.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05378803 |
| Source dataset | uspto-grants-1995_01 |
| ORD ID | ord-4950d19b2e844551beb1587c71797ce3 |
| Source note | uspto-grants-1995_01 |