4-Methylmorpholine → HCID 127261982, compound

Participants

Reaction Steps

Condensation of Boc-Leu-OH (liberated from 5.0 g. of the monohydrate by heating at 45° C. under vacuum) and H-MePhe-NH2 and H-MepheNH2 (mixture of isomers) hydrobromide salt (4.92 g.) and N-methylmorpholine (two 2.31 g. portions) in tetrahydrofuran (50 ml.) for 45 min. at 25° C. and then overnight at room temperature, isolation of the crude product (5.94 g.) by ethyl acetate extraction, and purification by HPLC on silica gel gave Boc-Leu-MePhe-NH2 and Boc-Leu-Mephe-NH2 (mixture of isomers) as a colorless foam (3.8 g., 48% yield).

Provenance & Evidence