Hydrochloric Acid → HCID 131718827, compound

Participants

Reaction Steps

De-(1,1-dimethylethoxy)carbonylation of Boc-Leu-MePhe-NH2 and Boc-Leu-Mephe-NH2 (mixture of isomers, 3.7 g.) with hydrogen chloride in ethyl acetate (4.4N, 25 ml.) for 2 hr. at room temperature and isolation of the product by precipitation with ether gave H-Leu-MePhe-NH2 and H-Leu-Mephe-NH2 (mixture of isomers) hydrochloride salt (2.63 g., 85% yield, m.r. 124°-127° C.).

Provenance & Evidence