3,4-dihydro-2H-pyran → 2H-Pyran, tetrahydro-2-(4-iodophenoxy)-

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Reaction Steps

In 1 l of four-necked flask, 178 g (0.81 mol) of p-iodophenol, 81.68 g of dihydropyran and hexane were introduced and stirred for one hour. Then, 15 g of a cation exchange resin Amberlyst 15 (Rohm & Haas Co. "Amberlyst"®) was added thereto and stirred at room temperature overnight. Amberlyst 15 was removed by filtration and the filtrate was washed with an alkali and then with water. The oil layer was dried over sodium hydroxide and the solvent was distilled off to obtain 189.7 g (yield: 77%) of 4-[(tetrahydropyran-2-yl)oxy]iodobenzene.

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