Methanol → HCID 23677033, compound

HRID 1768920Notes

Reaction equation

HRID 1768920 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([OH:16])=[O:15])=[C:12]([S:17][C:18]3[N:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[N:19]=3)[N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.CO.C[O-].[Na+:32]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([O-:16])=[O:15])=[C:12]([S:17][C:18]3[N:19]=[C:20]([O:26][CH3:27])[CH:21]=[C:22]([O:24][CH3:25])[N:23]=3)[N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Na+:32]

Participants

5

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 157671394-(4-Chlorophenyl)-2-(4,6-dimethoxypyrimidin-2-ylthio)nicotinic acid

Product 1

HCID 23677033HCID 23677033, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.50 g (0.0012 mol) of 4-(4-chlorophenyl)-2-(4,6-dimethoxylpyrimidin-2ylthio)nicotinic acid in 7 ml of ethanol was added 0.30 g (0.0016 mol) of methanol solution of 28% sodium methylate at room temperature. After addition, the mixture was further stirred at room temperature for 20 minutes. The crystal thus precipitated was filtrated, and washed with ethanol and dried to obtain 0.46 g of a white powder of the aimed product.

Workup

  1. additionAfter addition
  2. customThe crystal thus precipitated
  3. filtrationwas filtrated
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-0607e1bb41124cc69ebc204d14066bce
Source dataset
uspto-grants-1995_01
Patent number
US05380700

Reaction notes

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