Hydrogen Bromide → 2-Bromo-4-(4-chloro-phenyl)-nicotinic acid methyl ester

Participants

Reaction Steps

To a solution of 80.0 g (0.28 mol) of 1-cyano-1-methoxycarbonyl-4-(N,N-dimethylamino)-2-(4-chlorophenyl)-1,3-butadiene in 100 ml of acetic acid, an acetic acid solution of 25% HBr was then gradually added dropwise at room temperature with stirring. After the dropwise addition, the resultant mixture was stirred at room temperature for 3 hours. The reaction mixture was then poured into ice water to precipitate a crystal. The crystal thus precipitated was filtrated out and washed with water and dried to obtain 75.0 g of a white crystal of the aimed product.

Provenance & Evidence