反应详情

温度

80 °C

To a solution of 50.0 g (0.15 mol) of methyl 2-bromo-4-(4-chlorophenyl)nicotinate in 300 ml of dimethylsulfoxide, 60 ml of 30% sodium hydroxide was added and stirred at 80° C. for 3 hours. The mixture was then poured into water and washed with 300 ml of ethyl acetate. Thereafter, the aqueous layer was acidified with 10% HCl to precipitate a crystal, which was then filtrated out. The crystal thus precipitated was washed with water and isopropyl ether, and dried to obtain 41.0 g of a white crystal of the aimed product.

1. washwashed with 300 ml of ethyl acetate
2. customto precipitate a crystal, which
3. filtrationwas then filtrated out
4. customThe crystal thus precipitated
5. washwas washed with water and isopropyl ether
6. customdried