2,4-Diamino-6-chloropyrimidine → HCID 18946289, compound

HRID 1768944Notes

Reaction equation

HRID 1768944 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([NH2:9])[N:3]=1.[NH:10]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([N:10]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[C:4]([NH2:9])[N:3]=1

Participants

4

Reactant 2

HCID 674322,4-Diamino-6-chloropyrimidineHCID 68163Hexahydro-1,4-diazepine

Product 1

HCID 18946289HCID 18946289, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The analogous 1-(2,6-diamino-4-pyrimidinyl)homopiperazine was prepared by reaction of 2,6-diamino-4-chloropyrimidine with unprotected homopiperazine (5 mol equivalents) in ethanol in a sealed tube, following the procedure of Example 19. Yield of the obtained base: 91.3%, mp. 62°-72° C.

Sources & evidence

ORD record
ord-e319984e99d743439fad2d21f41114b4
Source dataset
uspto-grants-1995_01
Patent number
US05380724

Reaction notes

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