Benzamide → HCID 3075941, compound

Participants

Reaction Steps

Using the procedure of Example 30 but at 50° C. and replacing tert-pentylamine by tert-butylamine and 2-(3-chloropropoxy)-N-1H-indol-4-yl)benzamide by 2-(4-bromobutoxy)-N-(1H-indol4-yl)benzamide, and with chromatography on silica (eluant:CHCl3 /acetone/TEA of 6:3:1), the residue was taken up in ether to obtain 2-[4-[1,1-dimethylethylamino)-butoxy]-N-(1H-indol-4-yl)benzamide melting at 147° C. The acid fumarate which melted at 224°-225° C. with sublimation after crystallization from ethanol, was prepared.

Provenance & Evidence