(+-)-Mercaptosuccinic acid → HCID 18946335, compound

HRID 1769003Notes

Reaction equation

HRID 1769003 reaction equation
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:13]1[CH:35]=[CH:34][C:16]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[CH2:21][CH2:20]2)=[O:18])=[CH:15][CH:14]=1)[C:9](=[O:12])[CH2:10]Cl)([CH3:4])[CH3:3].[SH:36][CH:37]([CH2:41][C:42]([OH:44])=[O:43])[C:38]([OH:40])=[O:39]>>[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:13]1[CH:35]=[CH:34][C:16]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[CH2:21][CH2:20]2)=[O:18])=[CH:15][CH:14]=1)[C:9](=[O:12])[CH2:10][S:36][CH:37]([C:38]([OH:40])=[O:39])[CH2:41][C:42]([OH:44])=[O:43])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 6268(+-)-Mercaptosuccinic acid2×HCID 9807390HCID 9807390, compound

Product 1

HCID 18946335HCID 18946335, compound

Procedure

Analogously to Example 1, 1-{4-[N-(2-isopropoxyethyl)-N-chloroacetylamino]-benzoyl}-4-[2-(4-chlorophenyl)-ethyl]-piperazine hydrochloride is reacted with DL-2-mercapto-succinic acid (=DL-thiomalic acid), yielding (±)-1-{4-[N-(2-isopropoxyethyl)-N-(1,2-dicarboxyethylmercapto-acetyl)-amino]-benzoyl}-4-[2-(4-chlorophenyl)-ethyl]-piperazine.

Sources & evidence

ORD record
ord-afb120f55a20478191f7e42fe119c234
Source dataset
uspto-grants-1995_01
Patent number
US05380726

Reaction notes

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