(+-)-Homocysteine → HCID 18946331, compound

HRID 1769004Notes

Reaction equation

Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:13]1[CH:35]=[CH:34][C:16]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[CH2:21][CH2:20]2)=[O:18])=[CH:15][CH:14]=1)[C:9](=[O:12])[CH2:10]Cl)([CH3:4])[CH3:3].[NH2:36][CH:37]([C:41]([OH:43])=[O:42])[CH2:38][CH2:39][SH:40]>>[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:13]1[CH:14]=[CH:15][C:16]([C:17]([N:19]2[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][C:27]3[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=3)[CH2:23][CH2:24]2)=[O:18])=[CH:34][CH:35]=1)[C:9](=[O:12])[CH2:10][S:40][CH2:39][CH2:38][CH:37]([C:41]([OH:43])=[O:42])[NH2:36])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 778(+-)-Homocysteine

HCID 9807390HCID 9807390, compound

Product 1

HCID 18946331HCID 18946331, compound

Procedure

Analogously to Example 1, 1-{4-[N-(2-isopropoxyethyl)-N-chloroacetylamino]-benzoyl}-4-[2-(4-chlorophenyl)-ethyl]-piperazine hydrochloride is reacted with DL-homocysteine (=2-amino-4-mercaptobutyric acid), yielding (±)-1-{4-[N-(2-isopropoxyethyl)-N-(3carboxy-3-amino-propylmercapto-acetyl)-amino]-benzoyl}-4-[2-(4-chlorophenyl)-ethyl]-piperazine.

Sources & evidence

ORD record: ord-f62bb3ae7513415481f2eab6ff263578
Source dataset: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05380726

Reaction notes

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