Dimethylformamide → HCID 18946532, compound

Participants

Reaction Steps

6-Chloro-6-hydroxypyridine (Aldrich) (1.94 g, 15 mmol) in dry dimethylformamide (DMF) (3 ml) was added to a suspension of hexane washed sodium hydride (18 mmol) in dry DMF (11 ml). After stirring at room temperature for 2 hours, 8-bromo-octan-1-ol (3.15 g) was added. The mixture was warmed at 60° for 2 hours and left at room temperature for 16 hours. After conventional work-up and chromatography on silica, 8-(6'-chloro-2-pyridyl)oxyoctan-1-ol was obtained.

Provenance & Evidence