2,4-Dibromo-6-methylbenzothiazole → HCID 178422422, compound

HRID 1769022Notes

Reaction equation

HRID 1769022 reaction equation
Br[C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([Br:12])[C:5]=2[N:6]=1.[SH2:13].[Na]>CO>[Br:12][C:7]1[C:5]2[N:6]=[C:2]([SH:13])[S:3][C:4]=2[CH:10]=[C:9]([CH3:11])[CH:8]=1

Participants

4

Reactant 2

HCID 189465492,4-Dibromo-6-methylbenzothiazoleHCID 86586439Sodium hydrogen sulphide

Product 1

HCID 178422422HCID 178422422, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.1 g of 2,4-dibromo-6-methylbenzothiazole, 1.0 g of sodium hydrogensulfide and 30 ml of methanol were mixed and the obtained mixture was refluxed for one hour, cooled to room temperature and then distilled under reduced pressure to remove methanol. The residue was extracted with dichloromethane by adding water and dichloromethane. The dichloromethane layer was dried with anhydrous sodium sulfate and evaporated to obtain the title compound in a solid state (Yield: 84%).

Workup

  1. temperaturethe obtained mixture was refluxed for one hour
  2. distillationdistilled under reduced pressure
  3. customto remove methanol
  4. extractionThe residue was extracted with dichloromethane
  5. additionby adding water and dichloromethane
  6. dry with materialThe dichloromethane layer was dried with anhydrous sodium sulfate
  7. customevaporated

Sources & evidence

ORD record
ord-925037dfb85c4b21a4236cab805b288e
Source dataset
uspto-grants-1995_01
Patent number
US05380735

Reaction notes

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