Ammonia → HCID 11949321, compound

HRID 1769029Notes

Reaction equation

HRID 1769029 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH2:23][CH2:24][C:25]([O:27]C)=O)[O:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[NH3:29]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([CH2:23][CH2:24][C:25]([NH2:29])=[O:27])[O:11][C:12]=2[C:13]2[CH:14]=[CH:15][C:16]([S:19]([CH3:22])(=[O:20])=[O:21])=[CH:17][CH:18]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11949263HCID 11949263, compound

Product 1

HCID 11949321HCID 11949321, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Part 20) 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-oxazolepropionic amide is prepared by treating 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-oxazolepropionic acid, methyl ester with excess ammonia in methanol for 5 days, mp 193°-195° C.

Sources & evidence

ORD record
ord-db9883fc670f4e6eb232a939808736bd
Source dataset
uspto-grants-1995_01
Patent number
US05380738

Reaction notes

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