HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1769033Generated: October 30, 2026
Lithium Hydroxide → 1-[[(2-Ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(carboxy methoxy ethyl)-4-piperidinyl]methanone
https://huagongshe.com/reaction/1769033
Participants
| Role | Name | HCID | Charge |
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| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 57294109 | HCID 57294109 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | 1-[[(2-Ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(carboxy methoxy ethyl)-4-piperidinyl]methanone | HCID 131718829 | — |
Reaction Steps
Dissolve 1-[[(2-ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(carbomethoxy methoxy ethyl)-4-piperidinyl]methanone (0.9 g, 2.15 mmol) in tetrahydrofuran/water (20 mL, 1/1). Add lithium hydroxide monohydroate (932 mg, 8.5 mmol). Seal the flask and warm to 60° C. for 3 hours. Dilute with ethyl acetate/water, acidify and separate the organic phase. Dry (MgSO4), evaporate the solvent in vacuo, and purify by ion-exchange chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05380731 |
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| Source dataset | uspto-grants-1995_01 |
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| ORD ID | ord-17e85e41d4a7487383df2cb29d9ad0a1 |
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| Source note | uspto-grants-1995_01 |
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