HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1769043Generated: October 30, 2026
2-Methyl-2-butanol → 1-(4-Chlorophenyl)-2-methyl-2-(2-methylpropionyl)cyclopropane
https://huagongshe.com/reaction/1769043
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methyl-2-butanol | HCID 6405 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sulfoxonium, trimethyl-, iodide (1:1) | HCID 74498 | — |
| Reactant | 1-(4-Chlorophenyl)-2,4-dimethyl-1-penten-3-one | HCID 54408187 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-(4-Chlorophenyl)-2-methyl-2-(2-methylpropionyl)cyclopropane | HCID 15764680 | — |
Reaction Steps
185 ml of tert-amyl alcohol are added to a suspension of 61.3 g of sodium hydride in 200 ml of NMP heated to 50° C. so as to have a steady evolution of hydrogen. The solution obtained is cooled to 25° C. and 176 g of solid trimethylsulphoxonium iodide are added, followed by a solution of 162 g of 1-(4-chlorophenyl)-2,4-dimethyl-1-penten-3-one in 250 ml of NMP. The resulting mixture is heated at 60° C. for 30 min. The product obtained is left in the reaction mixture for the following stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05380741 |
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| Source dataset | uspto-grants-1995_01 |
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| ORD ID | ord-4b52d5e65894473f8709d10e3a5a75a8 |
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| Source note | uspto-grants-1995_01 |
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