Aluminum tert-butoxide → HCID 10351919, compound

Participants

Reaction Conditions

Reaction Steps

To 3.8 g (20.2 mmol) of 2-isopropyl-2-methoxy-4(R),6(R)-dimethyl-1,3-dioxane was added 4.97 g (20.2 mmol) of aluminum tert. butoxide and the resulting mixture was heated to 180° C. under nitrogen (over a 30 min. period) and maintained at this temperature for one hour while distilling tert. butanol formed. The residue was cooled and distilled (directly from the reaction flask) to afford 2.05 g (65%) of 2-isopropylidene-4(R),6(R)-dimethyl-1,3-dioxane (Formula V: R3 =R4 =CH3 ; R5 and R6 together are (R,R)--O--CH(CH3)CH2CH(CH3)O--), b.p. 75°-78° C./aspirator vacuum.

Provenance & Evidence