反应详情

温度

95 °C

A mixture of pyridine-2-carboxaldehyde ethylene acetal (20 g; 0.13 mol), 4-methoxybenzyl chloride (21.2 g; 0.13 mol), and sulfolane (5 ml) in a 250 ml reaction flask was heated under nitrogen to 95° C. with stirring for 4 hours and then the mixture was allowed to react at room temperature overnight. The organic solvent was decanted, the resulting gummy precipitate was triturated with ethyl acetate :hexane (2:8), refluxed with stirring, and cooled. The solvent was decanted to yield 1-(p-methoxybenzyl)pyridine-2-carboxaldehyde ethylene acetal chloride (Formula IX: R1 =R7 =H; R2 =4'--OCH3 ; Z- =Cl-).

1. customin a 250 ml reaction flask
2. customto react at room temperature overnight
3. customThe organic solvent was decanted
4. customthe resulting gummy precipitate was triturated with ethyl acetate :hexane (2:8)
5. temperaturerefluxed
6. stirringwith stirring
7. temperaturecooled
8. customThe solvent was decanted