Methanesulfonic Acid → HCID 19047558, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3,5-difluorobenzyl-2-(1,3-dioxolan-2-yl)pyridinium hexafluorophosphate (9 g; 0.021 mol), polyphosphoric acid (90 g), and 9 ml of methanesulfonic acid was heated at 110° C. for 7 hours and then stirred at room temperature overnight. The reaction mixture was poured into 200 ml of water and a warm solution of 9 g of potassium hexafluorophosphate in water was added with stirring. The resulting pale yellow solid product was filtered and dried to afford 6.5 g (86%) of 8,10-difluorobenzo [b]quinolizinium hexafluorophosphate (Formula IV: R1 =R7 =H; R2 =8,10--F2 ; X- =PF6-).

Provenance & Evidence