Water → HCID 18947047, compound

Participants

Reaction Steps

9.4 ml (15 mmol) of a 1.6M solution of butyllithium in hexane are added, at -70° C., to a solution of 3.5 g (12.5 mmol) of 5-tosyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole in 40 ml of dry tetrahydrofuran; after 15 min, 1 ml (16 mmol) of iodomethane is added, the mixture is then stirred at room temperature for 30 min and poured into 200 ml of water. The precipitate formed is filtered and washed with hexane; after purification on silica gel using the 1/9 ethyl acetate/hexane eluent mixture, there are obtained 3.16 g of a white solid. Yield 86%. Melting point: 158°-160° C.

Provenance & Evidence