Hydrogen Bromide → HCID 18947035, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.1 g (10.6 mmol) of 1-methyl-5-tosyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole and 3.1 g (32.9 mmol) of phenol in 43 ml of a 33% solution of hydrobromic acid in acetic acid, placed in a sealed tube, is heated at 90° C. in a water bath for 3 hours. The reaction mixture is then filtered and poured into 150 ml of water and then extracted with three times 150 ml of diethyl ether. The aqueous phase is evaporated to dryness and the residue washed with acetone. There is obtained 0.64 g of a pasty solid. Yield 27%.

Provenance & Evidence