Hydrochloric Acid → HCID 67790044, compound

Participants

Reaction Steps

A solution of 2.13 g (0.011 mol) of 1,3-dichloro-5,6-dihydro-4H-thieno[3,4-c]pyrrole and 2.5 ml of N,N-diisopropylethylamine in 25 ml of dimethylformamide is poured onto a mixture of 1.95 g (0.0125 mol) of 2-chloromethyl-1H-4,5-dihydroimidazole hydrochloride, 2.5 ml of N,N-diisopropylethylamine and 25 ml of dimethylformamide. The mixture is subjected to ultrasound for 8 h and is then evaporated under vacuum. The residue is dissolved in 75 ml of salt solution and extracted with 5 times 50 ml of methylene chloride. The organic solution is dried and then concentrated to produce a residue which is dissolved in 50 ml of isopropanol and treated with 14 ml of a 1N solution of hydrochloric acid in isopropanol. The crystals formed by cooling are filtered and washed with diethyl ether. 0.5 g of product is obtained. Melting point: 206°-213° C. (with decomposition).

Provenance & Evidence