Potassium Carbonate → HCID 53883730, compound

Participants

Reaction Conditions

Reaction Steps

13.18 g (0.0945 mol) of ethyl aminoacetate hydrochloride, 33.8 g (0.245 mol) of potassium carbonate and 60 ml of dimethylformamide are introduced, under argon, into a 250 ml round-bottomed flask. The mixture is cooled to 5° C. and 8.5 g (0.0315 mol) of 3,4bis(bromomethyl)thiophene in solution in 30 ml of dimethylformamide are added over 25 minutes. This mixture is stirred at room temperature for 67 h. The mixture is poured into 500 ml of ice-cold water and extracted 3 times with ether. The organic phases are washed 3 times with water, combined, dried, filtered and then concentrated under reduced pressure. There are obtained 1.57 g (0.007 mol) of product (yield 24%).

Provenance & Evidence