Potassium Carbonate → HCID 18947050, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 12.58 g (0.041 mol) of 2-chloro-3,4-bis(bromomethyl)thiophene in 40 ml of dimethylformamide is poured dropwise onto a mixture of 17.77 g of ethyl 2-aminoacetate hydrochloride, 45.5 g of finely powdered potassium carbonate and 80 ml of dimethylformamide, cooled to 5° C. The mixture is stirred at room temperature for 2 h, then poured onto 400 g of a water/ice mixture and stirred for a further 15 min. The mixture is extracted with 5 times 100 ml of diethyl ether, the ether phase is washed with twice 100 ml of salt solution, dried over magnesium sulphate and concentrated. 9.49 g of an oily product are obtained.

Provenance & Evidence